1994 Volume 47 Issue 6 Pages 676-692
Experimental and phase I clinical studies were performed to evaluate the efficacy and safety of once-daily administration of arbekacin (ABK). The results obtained were as follows:
1. ABK displayed dose-dependent, excellent antibacterial activity and post-antibiotic effects (PAE) against MRSA.
2. No significant difference was found between once-daily and divided administration regimens in protection against an experimental MRSA infection in mice.
3. There was no significant difference between once-daily and twice-daily administration of ABK in ototoxicity in guinea pigs or in nephrotoxicity in rats.
4. In the phase I clinical study using 200 mg single daily administration of ABK, no abnormal laboratory test results or symptoms were observed.
5. In the phase I clinical study of 5-day repeated administration of 200 mg/day of ABK, headache and increase in WBC sediment in the urine was noted in 1 volunteer; however these were not confirmed to be attributable to ABK. No abnormal laboratory test results were obtained other than increases in β2-microglobulin, NAG and γ-GTP levels, each of which returned to normal after the completion of ABK administration.
No abnormality was observed in the audiometry examination.
6. Maximum serum concentration(Cmax), serum half-life(T1/2β)and urinary recovery rate (0-48 hours)after single administration of 200mg of ABK, were 13.20μg/ml,2.30 hours and 86.75%, respectively.
There were no significant differences in pharmacokinetic parameters or urinary recovery rates between day 1 and day 5 in the 5-day repeated administration study. These findings suggest that once-daily administration regimen of ABK may be as effective and safe as divided administration regimen for the treatment of MRSA infection. Further clinical evaluation is required, however.
