Experimental Study on the Oncostatic Activity of Actinomycin J. II Effects on the Yoshida Ascites Sarcoma in Stock Rats

Abstract

In the previous paper, some fundamental aspects of the possible oncostatic activity of actinomycin J upon Ehrlich’s ascites cacinoma in mice was reported. The present study was attempted in order to compare the effects of the same preparation upon Yoshida ascites sarcoma in rats. Following two points were of particular interest in the study to be reported. (1) Determination of the optimal oncostatic dosage if there is any such effect in the antibiotic preparation upon Yoshida sarcoma. (2) Detection of a characteristic cytologic effect if there is any. It has been our experience that often a cytologic effect of a chemotherapeutic agent is more apparent in Yoshida ascites sarcoma than in Ehrlich’s ascites carcinoma.