1957 年 10 巻 5 号 p. 219-223
The quantitative analysis of streptomycin resistance in bacterial population occurring in the sputum was made by only a few investigators (Pyle1), Kozokai2), Mitchson3)). However, there is none of the quantitative studies concerning the change of population with respect to streptomycin resistance after cessation of streptomycin administration. It is known by routine method studies that streptomycin resistance is persistant (Fisher4)). The purpose of the present study is to test whether the bacterial population in sputum is permanently maintained and to observe the relationship between streptomycin resistance developed by streptomycin therapy at first made and the therapeutic effect of chemotherapy with isoniazid and PAS (isoniazid-PAS therapy) followingly made.
