Further Study on Griseoflavin Identification with Novobiocin

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Griseoflavin reported in 1951^1,2) is an antibiotic produced by a streptomyces strain No. 160. This antibiotic is interesting in its acidic nature²⁾ and low toxicity, but on account of its low yield, investigation has been greatly hindered.

In 1955, novobiocin was discovered independently in separate 3 laboratories⁴⁾. When we compare griseoflavin with novobiocin, a remarkable resemblance can be noticed between them in their antibacterial spectrum, toxicity and papergrams. Recently a sample of novobiocin monosodium salt was made available to us, so we carried out a comparison on the biological and physicochemical properties.