Studies on Antifungal Activity of Variotin

Abstract

With the recent development of antibiotic therapy and with the frequent application of corticosteroid hormones, incidence of microbisme substitué and fungal diseases, respectively, are reported to be increasing^1,2). In these circumstances, studies on antifungal agents have been carried out by many investigators, and good many antifungal drugs were examined in dermatomycosis³⁾, though only a few antibiotics were applied to internal fungous diseases⁴⁾.

The present authors studied the antifungal activity of variotin, a new antifungal antibiotics discovered by Sumiki, Umezawa, Yonehara, etc. in the Institute of Applied Microbiology of Tokyo University, as well as certain characteristics concerning chemotherapeutic effect. The results of experiments are reported in this paper.