Original Articles
Cephalomycin, A New Antiviral Antibiotic. I Studies on Biological and Chemical Properties
1960 年 13 巻 2 号 p. 143-154
詳細
1960 年 13 巻 2 号 p. 143-154
Among antiviral antibiotics from Streptomyces, ehrlichin1), cardicin2), abikoviromycin3), achromoviromycin5) and myxoviromycin6), only achromoviromycin was described to be effective against Japanese B encephalitis virus. As a chemical agent, PANS7) was clinically applied to Japanese B encephalitis. Yet, no substance possesses a complete suppressive effect on Japanese encephalitis clinically.
In our laboratory, soil-isolates of streptomyces had been examined for their activities against Japanese B encephalitis virus along with their activities against bacteria, cancers and others. As a result, culture broth of a strain of streptomyces, No. Z-1120, was found to contain a substance, active against Japanese encephalitis virus in vitro as well as in vivo. This strain was isolated from a soil sample obtained at Honmonji temple, Ikegami, Ohta-ku, Tokyo. Since the active principle was extracted from the culture broth and has been proved to be a new substance, it was given the name of cephalomycin by Hata and others8). The present paper deals with mycological studies on the strain No. Z-1120, a source of cephalomycin, fermentation and extraction processes and chemical, physical and biological properties of cephalomycin.
