Activity of Angustmycins Against Experimental Infections and Transplantable Tumors

抄録

As reported in the previous papers^1–3), angustmycins A and C were observed to exhibit antimicrobial activity against gram-positive organisms and mycobacteria in synthetic or semisynthetic media; but their activity markedly decreased in organic media. Their antimicrobial effects were reversed by guanine, guanosine, adenosine, xanthosine, inosine and other related substances. The chemical structures of angustmycins were determined by Yüntsen.^4,5) A is 6-amino-9-(L-1,2-fucopyranoseenyl)-purine and C is 6-amino-9-(β-D-psicofuranosyl)-purine. The in vivo activity of angustmycin against some of experimental infections and transplantable tumors in animals was investigated, and the result are presented in this paper.