Effect of Angustmycin A on Incorporation of ³²P and ¹⁴C-Amino Acids

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Nucleoside antibiotics, angustmycins A and C^1–3), were observed to exhibit inhibitory activity against experimental infections and transplantable tumors in animals⁴⁾. Their in vitro antimicrobial activities were demonstrated in synthetic media, but they were markedly decreased in organic media^5,6). Their activities were reversed by guanine, guanosine, adenosine, inosine, xanthosine and other related substances⁵⁾. These results as well as their chemical structures^2,3) suggested that angustmycins may act as antimetabolites in nucleic acid biosynthesis. The influence of angustmycins on ³²P and ¹⁴C-labeled amino acids incorporations of Bacillus subtilis was investigated and the results are described in this report.