Pharmacological Studies on Antifungal Antibiotic, Moldicin B

Abstract

Recently, several drugs are being clinically used as antifungal agents. In this connection, the development of drugs with wide and powerful antibiotic spectrum is expected .

Moldcidin B is a yellow needle crystalline pentane, which is produced from the Actinomyces No. 1068 and its variant strain. These strains are separated from the soil near Take hot spring, Fukushima Prefecture. The antibiotic spectrum of moldcidin B is wide. It is not only clinically used as ointment, tincture, or vaginal tablet for favus, trichomonas infection, etc., but also expected to be used for the internal application.

As we have had the chance of obtaining moldcidin B, we have investigated its pharmacological action upon the isolated organs, respiration, blood pressure, and the corticosterone. The following experimental results have been made available to us.