Abstract
Oxidation of symmetrical disulfide-type thiamines with hydrogen peroxide in acetic acid did not produce the monosulfoxides of the thiamines, but gave thiaminic acid, 2-[2'-methyl-4'-aminopyrimidyl- (5') ]-methylformamino-5-hydroxy-Δ^2-pentenyl-3-sulfonic acid, or its O-acyl ester as previously reported. In this paper, by the use of perbenzoic acid as an oxidizing agent, the monosulfoxides were prepared and confirmed as the new thiamine derivatives. One of these compounds, O-benzoylthiamine disulfide monosulfoxide was tested for the prevention of thiamine-deficiency in Uroloncha domestica, and it was found to posses approximately the same efficacy as that of O-benzoylthiamine disulfide. Furthermore, it was also found that the higher blood level of thiamine was reserved for a long time than in case of O-benzoylthiamine disulfide, when the monosulfoxide was orally or intravenously admistered in rabbits.
