Chemoprophylaxis of Poliomyelitis in Mice with Quinomycin (Studies on the Antibiotic Substances from Actinomycetes, XLVI)

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Since the publication of reports on the action of helenine¹⁾ and M-8450²⁾ against poliomyelitis in mice, this laboratory has been engaged in the sereening of streptomyces filtrates having chemoprophylactic effect against poliovirus infection in mice³⁾.

Streptomyces O-732 first called our attention since the culture filtrate of this strain showed anti-polio activity as well as antitumor activity. Extraction of the active principle(s) was attempted, and the final product obtained in a crystalline form, later designated as quinomycin complex, was shown to be highly active against gram-positive organisms, HeLa cells, Ehrlich ascites tumore^4,5), and against poliovirus infection in mice. The crystal, however, was probed to be consisting of three entities designated as A, B, and C the quinomycin A being identical with echinomycin⁶⁾ which is a cyclic polypeptide containing quinoxaline moiety.

The present paper is chiefly concerned with prophylactic effect of quinomycin complex and quinomycins A, B, and C in preventing paralysis of the mice infected with MEF₁ strain of type II poliovirus. two synthetic compounds containing quinoxaline moiety were also examined in the same manner.