Studies on Primocarcin. II Isolation and Properties of Primocarcin

抄録

In the course of our antitumor antibiotic screen program using Ehrlich ascites carcinoma, a new antibiotic primocarcin was isolated in crystalline from the culture filtrate of an actinomycete designated as Nocardia fukayae¹⁾. The antibiotic is a water-soluble neutral compound having the formula C₈H₁₂N₂O₃ and shows marked tumor-inhibitory effects against ascites type of Ehrlich carzinoma and Crocker sarcoma 180. This paper deals with fermentation and isolation procefures as well as the chemical and biological properties of the antibiotic.