The Journal of Antibiotics, Series A
Online ISSN : 2435-5135
Print ISSN : 0368-1173
ISSN-L : 0368-1173
Original Articles
Studies on Antibiotics from Helminthosporium sp. Fungi. V Zizanin, A New Antifugal Antibiotic Produced by Helminthosporium Zizaniae
Keijirō Ishibashi
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ジャーナル フリー

1962 年 15 巻 2 号 p. 88-92

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In the previous reports1–5), it was found that Helminthosporium sp. fungi in which Ophiobolus miyabeanus, Helminthosporium turcicum, H. panici-miliacei, H. leersii, H. zizaniae and O. heterostrophus produced ophiobolin (m.p. 181°C, C24H32O4), and Pyrenophora avenae produced pyrenophorin (m.p. 174–175°C, C24H30O9.

As mentioned above, a strain of H. zizaniae was found to produce ophiobolin, was obtained as crystalline form from the culture fluid on the same strain.

The new antibiotic was isolated from culture fluid of Helminthosporium zizaniae by the author, and it wa named zizanin.

In this paper, the author wished to describe isolation, purification, chemical and physical properties and microbiological spectrum of zizanin.

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© 1962 JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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