Original Articles
Pyrrolnitrin, a New Antifungal Antibiotic Microbiological and Toxicological Observations
1965 年 18 巻 5 号 p. 211-219
詳細
1965 年 18 巻 5 号 p. 211-219
Pyrrolnitrin (hereinafter referred to as PN) is a new antifungal antibiotic, recently isolated from Pseudomonas pyrrocinia n. sp. by Arima et al1)., and the chemical structure of this substance is established as follows : 1)
The above chemical structure was confirmed synthetically by this laboratories2).
Comprehensive studies of PN were undertaken to observe its antimicrobial activity in vitro, its distribution in the body and excretion after oral administration, its therapeutic activity on animals with experimentally-induced fungal infection and its toxicity.
The antifungal activities of PN were compared with those of other widely used antifungal agents.
