Sinanomycin (Netropsin) Produced By Streptomyces Sp. No. 7618 Studies on the Antibiotic Substances From Actinomyces, XXXVII

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In our systematic research of Streptomyces antibiotics, a basic antimicrobial agent was obtained in a crystalline form from the culture filtrate of a Streptomyces sp., No. 7618, which was isolated from a soil sample collected near the Lake Noziri, Sinano, Japan.⁽¹⁾⁽²⁾ The antibiotic was named Sinanomycin. It exhibited a very wide antimicrobial spectrum, including the bacteriostatic activity on Gram positive, Gram negative, and acid fast organism and the antiviral actlvity. Especially, it exerted some protective effect against influenza A virus (PR8) infection of mice when given intraperitoneally 30 minutes before the nasal inoculation of the virus. The author studied the known antibiotics having antiviral activity and he considered that his antibiotic would be a new one⁽¹⁾⁽²⁾ and named it sinanomycin. However, soon later, he found that the antibiotic is similar in many properties to netropsin which was reported by Finley, et al.⁽³⁾⁽⁴⁾ When the infrared absorption spectrum of sinanomycin sulfate was compared with that of Finley’s reports, it could not be identified as netropsin, because it exhibited no sharp peaks. Using a purified sample of netropsin hydrochloride, which had been sent from the Research Laboratory of Chas Pfizer and Co., several chemical and biological properties were examined. On the basis of the ultraviolet and the infrared absorption spectra, sinanomycin was identified as netropsin. In this paper, the results of our studies on sinanomycin are presented.