1956 年 9 巻 4 号 p. 141-146
A research for new anti-tumor substances produced by soil actinomycetes has been carried in our laboratory for the past several years. As a result, several aspects of cazinophilin were found and are reported in the preceding papers(1)(2)(3). Recently, the fermentation broth of a strain, isolation #V621, having growth-inhibitory activity against gram positive and gram negative bacteria, was found to exert destructive effect upon the cells of Ehrlich carcinoma and Yoshida sarcoma which resulted in the prolongation of the survival period of the host animals. The broth also showed virucidal activity in vitro against Newcastle disease virus and influenza virus and parasitocidal activity against ascaris.
Then, isolation of active principles from the fermentation broth was tried and at least several substances were obtained. A group of these active substances which were found to be previously underscribed compounds was named Mitomycin. It is the purpose of this paper to describe generally antibiotic producing strain, assay, cultivation and properties of mitomycin.
