Abstract
In the foregoing studies (Arch. hist. jap. Vol. 9, p. 371 and 549), the effects of surplus histamine to the peptic and the parietal cells of rats were investigated. Then ‘productin’vacuoles in the surface-cells of the gastric mucous membrane, to which FUJIE (1952) has called our attention, were observed on the same material.
In normal rats or rats injected with histamine 1 time, ‘productin’ vacuoles were discharged from the surface-cells remarkably during 1-1.5hrs. after administration of diet, then they accumulated again in the cells, as shown in graph 1 and 2 (p. 233, 234). Their discharge seemed to be stormy. However, in rats injected with histamine 15-60 times, the‘productin’vacuoles were generally numerous in the cells after administration of diet, as shown in graph 3, 4, 5 and 6 (p. 234, 235). The discharge of the vacuoles were lower and more durable against the former stormy one. The reason of this irregularity of the endocrine function of the surface-cells has not been understood.
One of the findings in the foregoing studies, a prolonged remarkable production of secretion granules in the peptic cells after an increase of histamine injection and an administration of diet, and the similar results in the parietal cells are understood supposing the“low and durable secretion of productin”. Namely, the accumulation of histamine in the body and the durable addition of‘productin’on it must bring about the phenomena mentioned above.
The other findings, that with the increased histamine injection the discharge of secretion granules in the peptic cells went down and that in the parietal cells was promoted, were not explained at that time. But it is understood, if the observations on the‘productin’vacuoles in this paper are combined with the theory, established by FUJIE, that less splitted products of histamine promote the discharge in the parietal cells and more splitted ones promote the discharge of the vacuoles in the peptic cells, and the theory of the author, obtained in the foregoing studies, that the splitting capability of the body against histamine goes down with the daily injection of histamine. In rats injected with histamine many times, the less splitted products of histamine (which promote the discharging in the parietal cells) increase and accumulate in the body, with the increment of histamine, whereas more splitted products of it (which promotes the discharging vacuoles from the peptic cells) not only increase but also decrease relatively against the increment of histamine in the body.
