食餌中の蛋白質量と胃腺細胞機能との関係に就ての実験的研究

II. 胃粘膜表在細胞 Productin 空胞 (藤江) の消長とその意義に就て

抄録

Rats were fed with artificial food which contained 0, 20, 40, 60 or 80% of protein, and the fluctuation of productin-vacuoles (FUJIE) in the surface cells of the gastric mucosa was observed and was compared with the characteristic changes of the functional images in the peptic cells, which were seen in the same materials (Arch. hist. jap. Vol. 10, No. 2, p. 207).
In normal case (table 1), productin-vacuoles filled the cells at a starvation, decreased rapidly after an administration of diet and thereafter increased gradually. That is a transitory strong discharge of productin-vacuoles.
In the case of 0% protein diet feeding (table 2), discharge of productin-vacuoles was very inferior and many vacuoles were always accumulated in the cells. In the case of 20-80% protein diet feeding (table 3-6), discharge of productin-vacuoles was remarkable owing to the increment of protein content in the diet, and vacuoles in the cells were few. These phenomenon became more remarkable with the prolongation of feeding.
These results as well as the relationship between secretion granules and vacuoles in the peptic cells which was observed in the author's foregoing study can be explained almost completely with the productin theory of FUJIE. The author believes that the results obtained in the peptic cells are never accidental ones. On the other hand a correlation between an indirect factor (component of diet) and a direct factor (gastric hormone productin) for promoting the secretory function of the peptic cells was made more clear. These facts may verify FUJIE's productin theory.