Abstract
The author fed rats 1, 5, 10, 20 and 30 days after the total extirpation of the parotis gland or the parotis, submandibular and sublingual glands to confirm the ratiocination which can be reached theoretically from the internal secretion theory of salivary glands (OGATA), the gastric hormone productin theory (FUJIE) and the saliva histamine-splitting theory (FUJIE and author). The rats gained or lost weight till 10 days after the operation, but 20 or 30 days later they lost weight without exception. Histamine in blood of the operated rats showed a very high value. In normal rats histamine increases in the blood after the diet-admistration, then decreases during 2 or 3hrs., but in these operated rats it was found to have already increased before the diet-administration and it reached the extreme high value after the administration, not decreasing even 6hrs. later. On the other hand, various abnormal changes can be observed in the gastric mucous membrane. The author classified them in 9 ways, 1. dilatation of the capillary blood vessels and hyperaemia, 2. infiltration of the cells, 3. multiplication of connective tissue in the propria mucosae, 4. atrophy or degeneation of the gastric gland, 5. deficiency in the surface region of the mucosa, 6. bleeding on the surface of the mucosa, 7. atrophy of the mucosa, 8. local necrosis of the mucosa and 9. local scar in the mucosa. Many kinds of these changes can be observed with prolonged feeding after the extirpation of salivary glands.
In a case where rats are injected 1/100mg of parotin (salivary gland preparation) every morning and evening, the loss in weight can not be prevented but the histamine value in the blood at the starved condition approaches the normal value and the pathologic changes in the mucosa are positively mitigated.
According to the above results and the discussion based on them, it is believed that the total extirpation of the salivary glands brings about a surplus condition of histamine in the blood owing to the incomplete treatment of the gastric hormone productin (histamine-like substance) which had been secreted in the blood, because the ulcerous changes in the gastric mucosa caused by surplus histamine and the anti-histamic action of saliva absorbed into blood have been previously demonstrated by FUJIE.
