Abstract
Whether the pancreatic cells have been maintaining a faculty to perform the active secretory function after giving non-protein diet or not was studied so that the results such as the author has obtained in the former researches, might be made more clear, in these researches, the remarkable inferiority of the secretory function of the pancreatic cells in case of giving non-protein diet, the marked superiority in case of high protein diet, the superior function in case of histidine diet (histidine was added into non-protein diet), and the presence in great numbers or in small numbers of vacuoles in the gastric surface cells according to an inferiority and a superiority of the secretory function in the pancreatic cells were demonstrated.
Injecting histamine hydrochloride 3mg subcutaneously, the marked production of zymogen granules can be seen, similar to those of normal rats, and the soundness of the pancreatic cells in their secretory function is recognized. Injecting acetylcholine and eserine in order to stimulate the peripheral end of the parasympathetic nerve and the discharge of the gastric hormone productin from the gastric surface cells, the production of the granules can be seen only for a short time after the injection and there is no active discharge of productin.
Here, it is believed that the lack of protein resulting from a non-protein diet brings about not functional degeneration in the pancreatic cell itself but an inhibition in the discharge of productin from the gastric surface cells and that histidine in the diet can prevent this inhibition.
