Abstract
The effects of Histidine deaminase (Histidase), Diamine oxidase (Histaminase) and the anti-histamic substances on the action of the gastric hormone productin which was secreted into the blood as naturally as possible by the injection of Acetylcholin-Eserin, on the secretory function of the gastric peptic, parietal cells and the pancreatic cells were studied.
1. After the injection of Histidase, productin in the blood has not a capacity to promote the secretory function of the gastric peptic cells, but has a capacity to promote the copious discharge of secretory substance from the gastric parietal cells, and to promote the production of zymogen granules in the pancreatic cells. As regards these results, there are discrepancies if the Histidase injected is considered to decompose productin in the blood.
2. After the injection of Histaminase, productin in the blood promotes the vacuolization of the secretion granules produced in the peptic cells and promotes the discharge of secretory substance from the parietal cells and promotes also in a lesser way the production of zymogen granules in the pancreatic cells.
3. After the injection of heated Histaminase, superior production and inferior vacuolization of secretion granules in the peptic cells; production and discharge of secretory substance in the parietal cells; and considerable production of zymogen granules in the pancreatic cells were recognizable.
4. After the injection of the anti-histamic substance Restamine, the effects of productin are similar to those of the case in which Histidase was injected.
5. After the injection of Raw potato juice (solution of its aceton sediment), the anti-histamic action of which was demonstrated by FUJIE, the effects of productin are similar to those of the case in which Histaminase was injected.
6. Contrasted with the productin theory of FUJIE, and the results obtained by the injection of a histamine-histaminase mixture (SHIMIZU) and the results obtained by TOJYO in her study of the actional differences between histidine and histamine, the main point of similarity seems to be in the case of Histaminase injection. Here, productin is believed to be a substance of which the essential action is controlled and the action owing to the decomposed product of productin is caused by Histaminase. That is, the similarity between productin and histamine may be presumed.
