A hormone "productin" which was named by FUJIE, is secreted from the gastric mucosa and stimulates haematogenously the production of secretion granules in the pancreatic and the peptic cells. It's splitted substance brings about the vacuolization of the secretion granules of the peptic cells and then discharges it. In the other words, productin becomes the substance which promotes the secretion of gastric juice (i.e. gastrin). On the other hand, the functional movements of the pancreatic and the peptic cells, which can be recognized after the injection of histamine, are quite similar to the ones of productin, therefore it can be considered that productin is identical with histamine or a histamine-like substance (this Arch. Vol. 3).
Because there are no histochemical methods to determine histamine directly, the authors have tried to do research on the influences of a anti-histamic substance or histaminase to productin. We carried out the following experiments: 1. sesame oil was injected into the stomach of the rats with ligatured pylori, at the same time, Restamin (Rst. hydoric dimethyl aminoethyl benzhydoril aether, 10mg) or Desamina (Desa. histaminase, 0.1g) were injected subcutaneously. 2. subcutaneous injections of an extract of the pig's gastric mucosa and Rst. or Desa. at the same time. 3. subcutaneous injections of histamine solution and Rest. at the same time. 4. subcutaneous injection of an extract of the gastric mucosa, Rst. and an extract of the duodenal mucosa (secretin).
The results of these experiments show that the activity of productin is controled clearly by the injection of Rst. or Desa. and that the secretion granules of the peptic cells are vacuolized rapidly and then discharged. The control by Rst. is recognized in the case of histamine injection as well as in the other cases. Here also the authors can concluded upon the identity between productin and histamine.
According to the summarization of the results which were published previously by FUJIE et al and the ones here described, the authors believe that the true nature of productin must be histamine-itself or a histamine-like substance.
