Abstract
The further understanding of the mechanisms of the budding cell cycle networks requires the comprehensive map for the detailed signal transduction pathways and the integration of huge amounts of post-genomic data (DNA microarray and protein-protein interaction data) into such a map. The use of CADLIVE (1) constructed a detailed map of the budding yeast cell cycle, which consists of 184 molecules and 152 reactions, and integrated postgenomic data into the map by computationally exploring the signal transduction pathways. Consequently, the inconsistency between the detailed map and the post-genomic data greatly facilitated exploring novel or unexpected interactions among different processes. Biological predictions would be facilitated by exploring the interaction among the molecules that are located at distant processes on a map rather than by focusing on local signal transduction pathways intensively.
