抄録
A novel flow reactor dealing with subcritical and supercritical water was developed for synthesizing oligopeptides from amino acids. The adiabatic expansion method for quenching and depressurizing the system was adopted to reduce the hydrolysis reaction of products. In almost all the previous studies the temperature and pressure of the system or the reaction time are often focused on. On the other hand, there is hardly any knowledge of methods of quenching and depressurizing the system. We considered these processes important.
In this study we worked on the reaction where glycine, the simplest amino acid, is formed into oligoglycines. After heating and pressurizing the glycine aqueous solution without any catalysts, it was quenched and depressurized with the adiabatic expansion method. The diglycine was produced about 45 times as much as in a previous study using water-cooled method for quenching the solution. It suggests that when the oligomer produced in water at high temperature and under high pressure was quenched, it was not hydrolyzed because of the higher rate of quenching. What is more, the concentration of linear-dimer was more than that of cyclo-dimer. It suggests our method was more suitable to make long peptides from amino acids.
