Abstract
123 I- IMP SPECT was investigated in 6 cases with alcoholic Korsakoff's syndrome which revealed the manifest confabulation. The pattern of SPECT was variable but all of them demonstrated the reduced medial frontal lobe uptake of IMP. One of these patients was conducted the follow-up SPECT after the disappearance of the confabulation and the increased uptake of IMP in the frontal region was found. This result suggests that frontal lobe dysfunction was thought to be related to the mechanism of confabulation in Korsakoff's syndrome.
