Absorption of Bicozamycin and Its Ester Derivative in Yellowtail, Seriola quinqueradiata

Abstract

Absorption of bicozamycin (BCM) and its ester derivative (FR2054) was compared in yellowtail, Seriola quinqueradiata. Since the maximum concentration (C_max) of BCM in tissue following FR2054 dosing was 4.5 fold higher than that obtained by BCM dosing, an adequate tissue level could be achieved in the kidney and spleen.
This FR2054 was found in the blood and tissue in a short time after administration of FR2054 and its concentration decreased while BCM concentration increased inversely. In order to investigate the site of hydrolysis of FR2054 in fish body, the rate of hydrolysis in plasma and tissue homogenate was investigated. Most hydrolysis of FR2054 was occurred in the plasma, suggesting that the absorbed FR2054 is hydrolyzed gradually to BCM while circulating in the blood stream.