Hyposensitization Therapy

Abstract

Practice of Hyposensitization therapy was presented. The following criterions were notified for the technique. 1) Dosage: Half of an dose which gave a moderate reaction on intradermal skin testing was used as initial dose, and increased up to maintenance dose weekly. After reached the maintenance dose switched the injection to monthly. All injections were given subcutaneously. 2. Signs which would indicate alteration of dosage: After the injection, if local swelling more than 5 cm, unusual pain, or any systemic reaction occured momemtarily or within four hours, the next dose was reduced. All patients had to wait at least 15 minutes after the injection. Intervals of the injection up to 14 days, dosage might be increased regularily. Dosage might be repeated if the interval did not exceed 28 days. After this interval the dosage had to be reduced by 25% for each week over four weeks. 3) Maintenance dose: If the patients could tolerate up to recommended dose: depends the strength of antigenicity, it was maintenance dose, otherwise the maximum dose which did not produce any untoward reaction was used as maintenance. 4) Discontinuing of the hyposensitization therapy was considered after 2 year nonsymptomatic period.