Studies on N-Benzenesulfonyl-β-Alanine Hydrazide (KH-125) : II.Suppressive Effect on Adjuvant Arthritis in Rats

Abstract

Effect of N-benzenesulfonyl-β-alanine hydrazide (KH-125) on adjuvant arthritis was compared with that of 6-mercaptopurine (6-MP). 1. In the prophylactic experiment on adjuvant arthritis, KH-125 and 6-MP suppressed swelling in adjuvant injected and noninjected feet and also increase in arthritis score. KH-125 was considered to be 3 times safer than 6-MP. 2. KH-125 was also effective on the established arthritis. 3. Rebound of foot swelling occurring after withdrawal of KH-125 was not prominent.