Studies on N-Benzenesulfonyl-β-Alanine Hydrazide (KH-125) : I.Suppression of Antibody Production to Sheep Erythrocytes

Abstract

Effect of N-benzenesulfonyl-β-alanine hydrazide (KH-125) on antibody production in mice was examined by Cunningham and Szenberg's plaque technique. 1. KH-125 dose-dependently suppressed the appearances of 19S and 7S plaque-forming cells (PFC) both in intraperitoneal and oral administrations. 2. The maximum suppression of the appearance of 19S PFC occurred when KH-125 was given at 48 hours after antigen injection. Side effects of KH-125 are now in progress.