抄録
The KM transfer into the inner ear fluid under injection of the vitamin B complex were studied. 56 adult guinea pigs were separated in two groups, one group were injected KM 200mg/kg intra musculary and another group were injected KM 200mg/kg intra musculary and VB complex (VB1 25mg, VB6 25mg and VB12 250mcg) 10mg/kg intra peritoneary. Each groups were devided in 4 subgroups and the drugs were injected 1, 2, 3, and 4 weeks. The animals were sacrificed after 24 hours of each last injection togather blood serum and the inner ear fluid. The KM concentration were measured by paper disc bioassy. Two animals of each subgroups were observed cochlear microphonics from the round window and observed histologically under light microscope. The result were as follows.:
The concentration of KM in the serum and the perilymph is almost equal between two groups such as KM injection group and KM+VB injection group.
KM were not detectable in the endolymph
Electrophysiological and histological study, the VB injected group are less affected than only KM injection group.
From these results the author concluded that the VB has prophylactic effect of ototoxity of KM but prophylactic mechanism is not influence the KM transfer into the inner ear fluid.
