ラット脳幹破壊によるABR陽性緩徐波の変化について

抄録

Both components of the ABR, sequential fast wavelets and positive slow wave, originate from different anatomical structures with different electrophysiological mechanisms. Origins of the positive slow wave were studied using some destructive methods in rats. After the mechanical destruction of the right cochlea, lesions were made in several parts of the auditory brain stem structures. The wave forms of the positive slow wave and the fast wavelets were observed before and after the destructions. The lesions were examined by serial sections for microscopic examination.
Considering the results, the following conclusions were obtained:
1) The positive slow wave might have its generators in the several parts of the brain stem auditory pathway, that is, ipsilateral cochlear uncleus, contralateral superior olivary complex, contralateral nucli of the lateral lemniscus and contralateral inferior colliculus.
2) On the contrary, cochlea, ipsilateral lateral lemniscus and ipsilateral inferior colliculus are not essential to generate the positive slow wave.
It is presumed that the positive slow wave is likely to be generated by the gray matter in the brain stem structures and that the sequential fast wavelets are generated primarily by the white matter.