Sensorineural Hearing Loss and Immunological Abnormalities
1991 Volume 34 Issue 2 Pages 110-116
Details
1991 Volume 34 Issue 2 Pages 110-116
Immunological study was performed in 83 patients with sensorineural hearing loss, including 41 patients with idiopathic bilateral sensorineural hearing loss, 7 Meniere's disease, 6 low tone deafness, 6 sudden deafness, 5 unilateral deafness, 11 other fluctuating sensorineural hearing loss, and 7 fixed sensorineural hearing loss.
The results were as follows:
1) Circulating immune complex was investigated in 83 patients and high immune complex titers (over normal means+2SD) were found in 41 cases of C1q SP RIA group and in 22 cases of mRF SP RIA group, especially patients of idiopathic bilateral sensorineural hearing loss showed high titers of immune complex on C1q SP assay.
2) Anti-DNA antibody assay showed high titers (over 2 times normal means) in 7 cases.
3) Anti-cardiolipin antibody assay showed high titers (over 2 times normal means) in only 3 cases.
4) Immunoglobulin test were performed in 31 patients and 12 cases showed high titers of IgG.
5) 11 cases (in 37 cases) showed positive antinuclear antibody. But anti-ENA antibody was not demonstrated.
6) Totally in 53 out of 83 cases, immunological abnormalities were demonstrated.
