Immunological study was performed in 83 patients with sensorineural hearing loss, including 41 patients with idiopathic bilateral sensorineural hearing loss, 7 Meniere's disease, 6 low tone deafness, 6 sudden deafness, 5 unilateral deafness, 11 other fluctuating sensorineural hearing loss, and 7 fixed sensorineural hearing loss.
The results were as follows:
1) Circulating immune complex was investigated in 83 patients and high immune complex titers (over normal means+2SD) were found in 41 cases of C
1q SP RIA group and in 22 cases of mRF SP RIA group, especially patients of idiopathic bilateral sensorineural hearing loss showed high titers of immune complex on C
1q SP assay.
2) Anti-DNA antibody assay showed high titers (over 2 times normal means) in 7 cases.
3) Anti-cardiolipin antibody assay showed high titers (over 2 times normal means) in only 3 cases.
4) Immunoglobulin test were performed in 31 patients and 12 cases showed high titers of IgG.
5) 11 cases (in 37 cases) showed positive antinuclear antibody. But anti-ENA antibody was not demonstrated.
6) Totally in 53 out of 83 cases, immunological abnormalities were demonstrated.
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