Annals of Vascular Diseases
Online ISSN : 1881-6428
Print ISSN : 1881-641X
ISSN-L : 1881-641X
The 2024 Takayasu Mikito Prize
A Multifaceted Approach to Abdominal Aortic Aneurysm
Katsuyuki Hoshina
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JOURNAL OPEN ACCESS

2025 Volume 18 Issue 1 Article ID: ra.24-00137

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Abstract

The underlying mechanisms of abdominal aortic aneurysms (AAAs) are not fully understood. Given the multifactorial nature of AAA development and progression, a comprehensive approach is essential. Throughout my academic career, I conducted various studies on AAA. To better understand this mechanism, I initially developed an elastase-infused rat AAA model and applied it to nanoparticle drug delivery systems. While open surgery has traditionally been the standard treatment for AAA, endovascular aneurysm repair (EVAR) has seen significant advancements over the past 25 years. However, insufficient evidence exists regarding this novel treatment, particularly in Japan. To address this issue, we analyzed extensive datasets on EVAR using various registries, including the Japanese Committee for Stent Graft Management. Furthermore, through medical–engineering collaboration, simulation methods were utilized to generate evidence addressing clinical questions encountered in practice.

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© 2025 The Editorial Committee of Annals of Vascular Diseases

This article is licensed under a Creative Commons [Attribution 4.0 International] license.
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