Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes

Carlos A. Hinojosa; Javier E. Anaya-Ayala; Hugo Laparra-Escareno; Lourdes Mena-Hernandez; Rodrigo Barquera; Jose I. Martínez-Quesada; Julio Granados

doi:10.3400/avd.cr.22-00094

This article has now been updated. Please use the final version.

Takayasu’s Arteritis in Mexican Monozygotic Twins: Analysis of Human Leukocyte Antigens (HLA) Haplotypes

Carlos A. Hinojosa , Javier E. Anaya-Ayala, Hugo Laparra-Escareno, Lourdes Mena-Hernandez, Rodrigo Barquera, Jose I. Martínez-Quesada, Julio Granados

Author information

Carlos A. Hinojosa Corresponding author
Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Masters and Doctorate program, Universidad Nacional Autonoma de México
Javier E. Anaya-Ayala
Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Masters and Doctorate program, Universidad Nacional Autonoma de México
Hugo Laparra-Escareno
Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Masters and Doctorate program, Universidad Nacional Autonoma de México
Lourdes Mena-Hernandez
Department of Transplantation, Division of Immunogenetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Rodrigo Barquera
National School of Anthropology and History
Max Planck Institute for the Science of Human History
Jose I. Martínez-Quesada
Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Masters and Doctorate program, Universidad Nacional Autonoma de México
Julio Granados
Department of Transplantation, Division of Immunogenetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
National School of Anthropology and History

Keywords: Takayasu’s arteritis, monozygotic twins, human leukocyte antigens

JOURNAL OPEN ACCESS Advance online publication

Article ID: cr.22-00094

DOI https://doi.org/10.3400/avd.cr.22-00094

The final version of this article is now available: Vol. 16 (2023), No. 1 pp. 73-76

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Abstract

Takayasu’s arteritis (TA) is an idiopathic great vessel vasculitis that affects the aorta and its branches. This entity is associated with the major histocompatibility complex (MHC) genes. We studied DNA sequences of human leukocyte antigens (HLA) haplotypes in one pair of Mexican monozygotic twins affected by TA. HLA alleles were determined by sequence-specific priming. Genetic testing of the HLA haplotypes in both sisters were A*02 B*39 DRB1*04 DQB1*03 : 02/A*24 B*35 DRB1*16 DQB1*03 : 01. These results confirm that within the MHC are genes that determine genetic susceptibility to develop TA and sustain genetic heterogeneity of this disease among populations.

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