Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report

Yohei Yamamoto; Hidetoshi Uchiyama; Masahiro Oonuki

doi:10.3400/avd.cr.23-00009

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Use of Recombinant Human Soluble Thrombomodulin in a Patient with Disseminated Intravascular Coagulation Associated with Abdominal Aortic Aneurysm: A Case Report

Yohei Yamamoto ^† , Hidetoshi Uchiyama ^†, Masahiro Oonuki

著者情報

キーワード: abdominal aortic aneurysm, disseminated intravascular coagulation, thrombomodulin

ジャーナルオープンアクセス早期公開

論文ID: cr.23-00009

DOI https://doi.org/10.3400/avd.cr.23-00009

この記事には本公開記事があります。

The final version of this article is now available: Vol. 16 (2023), No. 3 pp. 210-213

詳細

抄録

We herein present a case involving an 86-year-old man with abdominal aortic aneurysm complicated by symptomatic disseminated intravascular coagulation (DIC). The patient received preoperative treatment for DIC using recombinant human soluble thrombomodulin (rTM) followed by open surgical repair of the aneurysm. The patient’s coagulopathy cleared quickly after the start of rTM, and the intraoperative and postoperative course went smoothly. The patient was followed without anticoagulant medication, and there was no recurrence of DIC during 14 months of follow-up. The preoperative administration of rTM can be a useful choice to assist safe treatment of aortic aneurysm complicated by aneurysm-related DIC.

責任著者(Corresponding author)

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