USF-19A, a New Lipoxygenase Inhibitor from Streptomyces sp.

Toshikazu Komoda; Yasujiro Morimitsu; Hiroshi Hirota; Akira Hirota

doi:10.1271/bbb.59.924

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

USF-19A, a New Lipoxygenase Inhibitor from Streptomyces sp.

Toshikazu Komoda, Yasujiro Morimitsu, Hiroshi Hirota, Akira Hirota

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JOURNAL FREE ACCESS

1995 Volume 59 Issue 5 Pages 924-926

DOI https://doi.org/10.1271/bbb.59.924

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Abstract

USF-19A, a soybean lipoxygenase (SBL) and human 5-lipoxy-genase (5-LO) inhibitor, was isolated from Streptomyces sp. USF-19 strain. Its chemical structure was determined by spectroscopic evidence to be a new member of the antimycin antibiotic family. The IC₅0 value of USF-19A against 5-LO was 28. 0μM.

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