Platelet Responses after Stimulation with Lipopolysaccharide from Porphyromonas gingivalis

Emiko ISOGAI; Hiroshi ISOGAI; Kimiharu HIROSE; Hiroko MIMURA; Koichi KIMURA; Shunji HAYASHI; Masanobu HAYASHI; Nobuhiro FUJII; Yoshimi BENNO

doi:10.12938/bifidus1996.16.79

Platelet Responses after Stimulation with Lipopolysaccharide from Porphyromonas gingivalis

Emiko ISOGAI, Hiroshi ISOGAI, Kimiharu HIROSE, Hiroko MIMURA, Koichi KIMURA, Shunji HAYASHI, Masanobu HAYASHI, Nobuhiro FUJII, Yoshimi BENNO

Author information

Emiko ISOGAI
Department of Preventive Dentistry, School of Dentistry, Health Sciences University of Hokkaido
Hiroshi ISOGAI
Animal Experimentation
Kimiharu HIROSE
Department of Preventive Dentistry, School of Dentistry, Health Sciences University of Hokkaido
Hiroko MIMURA
Department of Preventive Dentistry, School of Dentistry, Health Sciences University of Hokkaido
Koichi KIMURA
Microbiology, Sapporo Medical University
Shunji HAYASHI
Microbiology, Sapporo Medical University
Masanobu HAYASHI
Department of Radiation Biology, Faculty of Veterinary Medicine, Rakuno Gakuen University
Nobuhiro FUJII
Microbiology, Sapporo Medical University
Yoshimi BENNO
Japan Collection of Microorganisms

Keywords: Porphyromonas gingivalis, lipopolysaccharide, platelets, polymorphonuclear neutrophils

JOURNAL FREE ACCESS

1997 Volume 16 Issue 2 Pages 79-82

DOI https://doi.org/10.12938/bifidus1996.16.79

Details

Abstract

A variety of bacterial components has been known to induce platelet aggregation. Here, we report that Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) caused direct aggregation of rabbit, but not human platelets. Pg-LPS also appeared to induce chemiluminescence response (CLR) in human polymorphonuclear neutrophils (PMNs) in whole blood or in serum. Human platelet aggregation was observed only in the PMN-platelet mixture system after stimulation with Pg-LPS.

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