Influence of Bile Salts on theβ-Glucosidase Activity of Bacteroides fragilis

Abstract

The influence of bile salts on theβ-glucosidase activity ofBacteroides fragiliswas investigated. Theβ-glucosidase is one of the cancer-associated bacterial enzymes. Theβ-glucosidase activity of intact cells and of sonicated cells ofB. fragiliswas higher in the buffer with sodium deoxycholate than in the buffer with sodium cholate or without bile salts. These findings suggest that the presence of bile salts, particularly deoxycholate, links to increase the β-glucosidase activity ofB. fragilisin the large intestine.