Effects of Lactobacillus gasseri SBT2055 on Dextran Sulfate Sodium-Induced Ulcerative Colitis Model in Rats

Abstract

The effects of a Lactobacillus gasseri SBT2055 (LG2055) on ulcerative colitis (UC) were studied in a rat model of UC induced by dextran sulfate sodium (DSS). Daily oral administration of LG2055 improved the characteristics of feces, body weight gain and food consumption. LG2055 treatment was also associated with a change of the spleen weight, and an improvement of the hematological parameters and histological findings of the large intestine. These findings indicate that LG2055 may be useful for the treatment and/or prevention of UC.