抄録
Quaternary ammonium salts (QAS), which are widely used as disinfectants, have the disadvantages of rusting and producing insoible salts in the presence of anionic surfactants. To deal with these drawbacks, we synthesized anti-rusting agent QAS by incorporating an alkyl phosphate anion to counter cationic surfactants. These new compounds have shown bactericidal effects and co-solubility. In this study, We evaluated the fungicidal activities of these new compounds, N-alkylN-2-hydroxyethyl-N, N-dimethylammonium alkyl phosphate (Pn-E analogues), N-alkylN-(2-hydroxy-3-phenoxy) propyl-N, N-dimethylammonium alkyl phosphate (Pn-PG1 analogues), as well as the effects of presently used disinfectants, [chlorhexidine digluconate (CHX), benzalkonium chloride (BAC), and digluconate (CHX), benzalkonium chloride (BAC), and alkyldiaminoethylglycine hydrochloride (ADE)], on pathogenic fungi, 3 strains ofCandida albicans, 2 strains ofCandida tropicalis, 1 strain ofCandida parapsilosis, 1 strain ofAspergillus niger, 2 strains ofAspergillus terreus, and 1 strain ofTrichophyton rubrum. Pn-E analogues and Pn-PG1 analogues at 0.1% concentration produced fungicidal effects onA niger only after 24 h but on other fungal strains after 1 h exposure. They showed the same fungicidal effects as those of BAC, CHX, and ADE on the 2 strains of C. tropicalis, and similar effects to those of BAC, CHX, and ADE inC. albicansdespite some differences among strains.
