Synthesis of (R)-and (S)-13-Hydroxy-10-oxo-trans-11-octadecenoic Acid and Their Antimutagenic Activity

MASAKAZU NOGUCHI; KATSUKI TAKAI; YOSHIHIKO TAKEI; RYOZO IRIYE

doi:10.4265/bio.5.91

Synthesis of (R)-and (S)-13-Hydroxy-10-oxo-trans-11-octadecenoic Acid and Their Antimutagenic Activity

MASAKAZU NOGUCHI, KATSUKI TAKAI, YOSHIHIKO TAKEI, RYOZO IRIYE

著者情報

キーワード: Antimutagen, Linoleic acid, Lipoxygenase-oxidation, Antitumor, Hydroxyenone

ジャーナルフリー

2000 年 5 巻 2 号 p. 91-95

DOI https://doi.org/10.4265/bio.5.91

詳細

抄録

(R)-and (S)-13-Hydroxy-10-oxo-trans-11-octadecenoic acid (1) were synthesized from (R)- and (S)-2-[(S)-O-methoxyethoxymethylmandelyloxy] heptanal (2R and 2S) and 10-oxoundecanol tetrahydropyranyl ether (3).(R)-acid showed antimutagenic activity against the UV-induced mutation of Escherichia coli.

責任著者(Corresponding author)

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