抄録
2, 2'-Dotriacontanedioylbis (1-palmitoyl-sn-glycero-3-phosphocholine) was synthesized chemically as a dimeric version of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine. Upon sonication in water, the bipolar lipid furnished a planar membrane of about 50 Å thickness with gel-to-liquid crystalline phase transition constants of Tm=53.4°C, ΔH=20.9kcal/mol, and ΔS=64.0 e. u. In an air/water interface, the lipid displayed unique surface pressuresurface area isotherms with a limiting area of 105-190 Å/molecule at 10-20°C. The lipid was a substrate of phospholipase A2 (Naja mocambique), which afforded 1-palmitoyl-sn-glycero-3-phosphocholine and dotriacontanedioic acid as final products.
