The 5, 6-Double Bond of Pyrimidine Nucleosides, a Fragile Site in Nucleic Acids

抄録

Our studies have revealed reagents that can attack the 5, 6-double bond of pyrimidine nucleosides; potassium permanganate and bisulfite. This review is a personal account of these studies, with a discussion on the vulnerable nature of this particular double bond to external nucleophiles and oxidizing agents. The finding that N (4) aminocytidine, produced on treatment of cytidine with bisulfite and hydrazine, is a strong mutagen is also described.