Molecular Mimicry of Human Tumor Antigen by Heavy Chain CDR 3 Sequence of the Anti-Idiotypic Antibody
2000 年 128 巻 3 号 p. 345-347
詳細
2000 年 128 巻 3 号 p. 345-347
We isolated and characterized an anti-idiotype monoclonal antibody (AR 42.1) which is capable of mimicking a distinct and specific epitope of MUC-1 antigen. The cDNA sequences coding for the AR 42.1 variable regions were determined. We found significant amino acid homology between complementary determining regions 3 (CDR 3) in the heavy chain of AR 42.1 and the determinant epitope sequence of MUC-1. This 10 amino acid sequence may represent an “internal image” of the anti-idiotype antibody to the MUC-1 antigen, and could be used for development of a MUC-1 surrogate for immunotherapy.
