1. The susceptibility of the glyoxals to hydrolysis by aldali and glyoxalase was studied. They were. arranged in the order of sensibility, methyiglyoxal, phenylglyoxal, hydroxymethylglyoxal, glucosone and glyoxal.
2. The lethal doses of the glyoxals for the rabbit were determined by injecting them subcutaneously and intravenously.
3. The fate of the glyoxals in the animal body was examined by analysing the blood and urine for their content of glyoxals, lactic acid and sugar. The finding that the injected glyoxals existed in the blood for a much longer time than was hitherto supposed, was a rather unexpected result, in view of their reactivity and of their susceptibility towards glyoxalase.
