STUDIES ON SECRETAGOGUES IN GASTRIC JUICE OF DOG

Abstract

1. The gastric juice secreted by sham feeding has no pharma-cologieal actions on the isolated frog heart, isolated rabbit intestine, and isolated rabbit uterus.
2. The actions of the gastric juice secreted by histamine in-jection on the isolated intestine and uterus of rabbit, are similar to those of histamine itself.
3. The gastric juice secreted by choline injection probably contains choline.
4. The actions of the gastric juices secreted by injection of parasympathomimetic drugs, such as muscarine, neurine, pilocarpine, physostigmine on the isolated frog heart and isolated rabbit intestine, are generally similar to those of the parasympathomime-tic drugs themselves.
5. The action of the gastric juice secreted by metbylguanidine injection on the isolated m. gastrocnemius of the frog, is similar to that of methylguanidine itself.
I wish to express my gratitude to Professor AL Tsudji for suggesting this study and for his guidance throughout the course of my research. My thanks are due to Professor M. Akainatsu also for his help and advice in making the pharmacological tests herein reported.