抄録
1. A remarkable acid change occurs in the blood shortly after it has been shed. With regard to the course of the change, the existence of “the first acid change”, reported by Havard and Kerridge, cannot be confirmed. Its whole course, including the so-called first and second stages, is regarded as being due to glycolysis.
2. The speed of the acid change in the blood decreases gradually during its course of many hours.
3. If the temperature of the blood is lowered, the commencement of the acid change is delayed, and its speed decreases.
4. NaF has a strong power to inhibit glycolysis, while, at the same time, it is apt to affect the corpuscular membranes and so bring about an acid change. K-oxalate can also depress the acid change due to glycolysis, though to a less extent than NaF. It stops the change completely for many hours after shedding, when used in a concentration of 0.2% with the sample in question kept at 16°C or below. Na-citrate has only a slight effect in depressing the acid change in shed blood, while hirudin and heparin exert no influence at all.
