INTERPRETATION OF THE ANTIVIRAL ACTIVITY OF VIRUSTATIC AGENTS IN A PHAGE/BACTERIUM SYSTEM
1958 Volume 45 Issue 3 Pages 177-184
Details
1958 Volume 45 Issue 3 Pages 177-184
Employing T2 phage/Escherichia coli strain B system, the mode of several antiviral substances on virus multiplication was investigated. The actions of these substances on virus and bacterial growth were compared quantitatively under identical experimental conditions as far as possible.
Correlation analysis of the results obtained revealed three typical types of mode of action of antiviral substances. In Type I, substances (cyanide and hydrogen peroxide) were found to exert parallel activities on virus and bacterial growth. On the other hand, Type II substances, such as gentisate and oxytetracycline, showed selective toxicity on virus growth, whereas Type III substance, represented by penicillin, showed selective activity on bacterial growth.
The author wishes to express his gratitude to Dr. T. Yanagita for his valuable suggestions and criticism during the course of this work.
He is indebted to the Ministry of Education for a Grant in Aid for Fundamental Scientific Research.
