The Journal of Biochemistry
Online ISSN : 1756-2651
Print ISSN : 0021-924X
SYNTHESIS OF L-CYSTEIC ACID AMIDE AND ITS HYDROLYSIS BY LEUCINE AMINOPEPTIDASE
SHUNJI OUCHIATSUSHI TANAKANOBUO IZUMIYA
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1959 年 46 巻 2 号 p. 185-188

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The improved method of synthesis of L-cysteic acid amide has been established, which utilizes the following reactions: (I) conversion of cysteic acid to cysteic acid ethyl ester; (2) amidation of the ester to yield cysteic acid amide.
Partially purified leucine aminopeptidase hydrolyzes cysteic acid amide at 0.11 per cent and 0.083 per cent at 0.025M and 0.01M substrate con-centrations, respectively, of the rate of L-leucinamide.
The authors wish to thank Prof. S. Shibuya for his interest in this study.
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© The Japanese Biochemical Society
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